Interações medicamentosas
Aripiprazole + Sufentanil
Gravidade: Grave
Aripiprazole and Sufentanil: major interaction.
Última atualização Fontes: UK SmPC
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Resumo
Opioids combined with other CNS depressants increase the risk of profound sedation, respiratory depression and hypotension. Aripiprazole has milder sedative effects but contributes to additive depression.
O que esta interação significa em palavras simples
Aripiprazole and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aripiprazole belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.
Por que acontece
Additive CNS and respiratory depression, with additive hypotensive effects.
O que fazer
Use the lowest effective sufentanil dose and monitor respiratory rate, sedation and blood pressure. Ensure appropriate monitoring and resuscitation capability in procedural settings.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
- Abilify 1 mg/mL Oral Solution - SmPC sections 4.3/4.5 (class statement: other CNS medicinal products with overlapping adverse reactions such as sedation; "caution should be used when aripiprazole is administered in combination with alcohol or other CNS medicinal products with overlapping adverse re… — electronic medicines compendium (UK SmPC)
Outras interações de Aripiprazole
- Aripiprazole + Pimozide Contraindicada
- Aripiprazole + Thioridazine Contraindicada
- Amisulpride + Aripiprazole Grave
- Aripiprazole + Arsenic trioxide Grave
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Grave
- Aripiprazole + Carbamazepine Grave
Outras interações de Sufentanil
- Alprazolam + Sufentanil Grave
- Amitriptyline + Sufentanil Grave
- Amobarbital + Sufentanil Grave
- Asenapine + Sufentanil Grave
- Baclofen + Sufentanil Grave
- Brexpiprazole + Sufentanil Grave
Perguntas frequentes
Can I take Aripiprazole with Sufentanil?
MediHelp rates the interaction as major. Aripiprazole and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with other CNS depressants increase the risk of profound sedation, respiratory depression and hypotension. Aripiprazole has milder sedative effects but contributes to additive depression.
How serious is the interaction between Aripiprazole and Sufentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective sufentanil dose and monitor respiratory rate, sedation and blood pressure. Ensure appropriate monitoring and resuscitation capability in procedural settings.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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