Interações medicamentosas
Brexpiprazole + Sufentanil
Gravidade: Grave
Brexpiprazole and Sufentanil: major interaction.
Última atualização Fontes: EMA SmPC
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Sufentanil is a highly potent opioid and, with brexpiprazole, can produce profound sedation, hypotension and respiratory depression. Opioid labeling advises caution when combining with other CNS depressants.
O que esta interação significa em palavras simples
Brexpiprazole and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brexpiprazole belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.
Por que acontece
Additive CNS and respiratory depression from opioid agonism and antipsychotic sedation.
O que fazer
Titrate sufentanil to the lowest effective dose and monitor respiratory rate, sedation and blood pressure continuously. Have airway support and reversal agents available in monitored settings.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Brexpiprazole
Outras interações de Sufentanil
- Alprazolam + Sufentanil Grave
- Amitriptyline + Sufentanil Grave
- Amobarbital + Sufentanil Grave
- Aripiprazole + Sufentanil Grave
- Asenapine + Sufentanil Grave
- Baclofen + Sufentanil Grave
Perguntas frequentes
Can I take Brexpiprazole with Sufentanil?
MediHelp rates the interaction as major. Brexpiprazole and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sufentanil is a highly potent opioid and, with brexpiprazole, can produce profound sedation, hypotension and respiratory depression. Opioid labeling advises caution when combining with other CNS depressants.
How serious is the interaction between Brexpiprazole and Sufentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sufentanil to the lowest effective dose and monitor respiratory rate, sedation and blood pressure continuously. Have airway support and reversal agents available in monitored settings.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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