Referência de medicamentos
Sufentanil
Sufentanil is a medicine in the class musculoskeletal. It is used for balanced anesthesia.
- Classe do medicamento: Musculoskeletal
- Indicado para: balanced anesthesia
Última atualização Fontes: US FDA label, EMA SmPC
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Pontos-chave
- Classe do medicamento
- Musculoskeletal
- Código ATC
- N01AH03
- Interações conhecidas
- 162 (Grave: 88 · Moderada: 63 · Leve: 11)
- Nomes comerciais
- 1
- Países e mercados
- 1
Para que é usado
Como funciona
Sufentanil is an opioid agonist. In balanced general anesthesia it has been reported to be as much as 10 times as potent as fentanyl.
Dose habitual em adultos (resumo da bula)
Analgesic adjunct to general anesthesia: doses up to 8 mcg/kg IV by slow injection or infusion; total dosage of 1 mcg/kg/hr or less recommended; individualize
Gravidez e amamentação
- Gravidez
- Unknown No human data on birth defects; no malformations in animals, but embryo loss in rabbits near the human dose. It crosses the placenta: use near delivery can depress the newborn's breathing; longer use can cause neonatal opioid withdrawal. Widely used epidurally in labour; have naloxone ready.
- Amamentação
- Safe Epidural or IV use in labour or briefly after birth transfers little into milk; LactMed: not a reason to stop. Limit postpartum use to a few days, then non-opioid pain relief. US labels: monitor for infant sedation and breathing problems; call a doctor if very sleepy or limp.
Efeitos adversos relatados
- Apnea
- Rigidity
- Bradycardia
- Pruritus (epidural)
Advertências de caixa preta
- Exposes users to addiction, abuse and misuse, which can lead to overdose and death; assess risk and reassess regularly. Life-threatening or fatal respiratory depression may occur, especially at initiation or dose increase. Concomitant benzodiazepines or other CNS depressants may cause profound sedation, respiratory depression, coma and death. CYP3A4 inhibitors may raise sufentanil levels and cause fatal respiratory depression; stopping a CYP3A4 inducer may also raise levels; monitor.
Contraindicações
- Hypersensitivity to sufentanil (e.g., anaphylaxis)
Quem deve ter cuidado
- Life-threatening respiratory depression; give only by trained persons with resuscitative equipment; respiratory depression may outlast analgesia
- Increased risk in COPD, elderly, cachectic or debilitated patients; monitor closely
- Skeletal muscle rigidity; manage with a neuromuscular blocking agent
Informe ao farmacêutico ou ao médico sobre gravidez ou amamentação, doença renal ou hepática, alergias e todos os outros medicamentos ou suplementos que você usa.
Principais interações (162)
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
- Brexpiprazole + Sufentanil Major
- Brompheniramine + Sufentanil Major
- Butorphanol + Sufentanil Major
- Cariprazine + Sufentanil Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Outros medicamentos desta classe
Perguntas frequentes
What is Sufentanil used for?
Sufentanil is a medicine in the class musculoskeletal. It is used for Balanced anesthesia, General anesthesia.
What side effects have been reported with Sufentanil?
Apnea, Rigidity, Bradycardia, Pruritus (epidural). Serious warning: Exposes users to addiction, abuse and misuse, which can lead to overdose and death; assess risk and reassess regularly.
Can Sufentanil be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No human data on birth defects; no malformations in animals, but embryo loss in rabbits near the human dose. It crosses the placenta: use near delivery can depress the newborn's breathing; longer use can cause neonatal opioid withdrawal. Widely used epidurally in labour; have naloxone ready. Breastfeeding: Safe. Epidural or IV use in labour or briefly after birth transfers little into milk; LactMed: not a reason to stop. Limit postpartum use to a few days, then non-opioid pain relief. US labels: monitor for infant sedation and breathing problems; call a doctor if very sleepy or limp.
What does Sufentanil interact with?
MediHelp lists 162 known interactions for Sufentanil. Major: 88 · Moderate: 63 · Minor: 11. The most serious include Alprazolam, Amitriptyline, Amobarbital.
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