Interações medicamentosas
Amikacin + Cefotaxime
Gravidade: Moderada
Amikacin and Cefotaxime: moderate interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Concurrent use of a cephalosporin with an aminoglycoside has been associated with additive kidney injury in some reports, particularly in patients with other risk factors. Aminoglycoside ototoxicity may also be a concern.
O que esta interação significa em palavras simples
Amikacin and Cefotaxime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Cefotaxime belongs to Anti Bacterial.
Por que acontece
Additive nephrotoxic potential, with aminoglycoside tubular toxicity possibly being aggravated by cephalosporins.
O que fazer
Monitor serum creatinine and amikacin levels during combined therapy, and keep the aminoglycoside course as short as possible. Maintain hydration and avoid other nephrotoxins.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Amikacin e Cefotaxime, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Cefotaxime
- Cefotaxime + Typhoid vaccine live Grave
- Cefotaxime + Cholera vaccine Moderada
- Cefotaxime + Dexamethasone-tobramycin Moderada
- Cefotaxime + Gentamicin Moderada
- Cefotaxime + Kanamycin Moderada
- Cefotaxime + Microbiota Moderada
Outras interações de Amikacin
- Amikacin + Cidofovir Contraindicada
- Adefovir + Amikacin Grave
- Amikacin + Amphotericin b Grave
- Amikacin + Amphotericin b deoxycholate Grave
- Amikacin + Atracurium Grave
- Amikacin + Bacitracin Grave
Perguntas frequentes
Can I take Amikacin with Cefotaxime?
MediHelp rates the interaction as moderate. Amikacin and Cefotaxime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of a cephalosporin with an aminoglycoside has been associated with additive kidney injury in some reports, particularly in patients with other risk factors. Aminoglycoside ototoxicity may also be a concern.
How serious is the interaction between Amikacin and Cefotaxime?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin levels during combined therapy, and keep the aminoglycoside course as short as possible. Maintain hydration and avoid other nephrotoxins.
What other medicines interact with Cefotaxime?
MediHelp also lists interactions of Cefotaxime with, for example, Typhoid vaccine live, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefotaxime page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
