Interações medicamentosas
Cefotaxime + Kanamycin
Gravidade: Moderada
Cefotaxime and Kanamycin: moderate interaction.
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Resumo
Kanamycin can cause kidney injury and hearing or vestibular damage. Cephalosporins have been reported to add to renal injury when given with aminoglycosides, although cefotaxime is only weakly nephrotoxic.
O que esta interação significa em palavras simples
Cefotaxime and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Possible additive nephrotoxicity; aminoglycoside accumulation with renal impairment increases ototoxicity risk.
O que fazer
Monitor serum creatinine and aminoglycoside levels, and ensure hydration. Consider audiometry with prolonged therapy and adjust kanamycin dose to renal function.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cefotaxime
- Cefotaxime + Typhoid vaccine live Grave
- Amikacin + Cefotaxime Moderada
- Cefotaxime + Cholera vaccine Moderada
- Cefotaxime + Dexamethasone-tobramycin Moderada
- Cefotaxime + Gentamicin Moderada
- Cefotaxime + Microbiota Moderada
Perguntas frequentes
Can I take Cefotaxime with Kanamycin?
MediHelp rates the interaction as moderate. Cefotaxime and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Kanamycin can cause kidney injury and hearing or vestibular damage. Cephalosporins have been reported to add to renal injury when given with aminoglycosides, although cefotaxime is only weakly nephrotoxic.
How serious is the interaction between Cefotaxime and Kanamycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and aminoglycoside levels, and ensure hydration. Consider audiometry with prolonged therapy and adjust kanamycin dose to renal function.
What other medicines interact with Cefotaxime?
MediHelp also lists interactions of Cefotaxime with, for example, Typhoid vaccine live, Amikacin, Cholera vaccine. The full list is on the Cefotaxime page.
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