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Interações medicamentosas

Cefotaxime + Typhoid vaccine live

Gravidade: Grave

Cefotaxime and Typhoid vaccine live: major interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

Oral live typhoid vaccine depends on viable attenuated Salmonella Typhi colonizing the gut. Cefotaxime is active against Salmonella and may reduce vaccine viability and the resulting immunity.

O que esta interação significa em palavras simples

Cefotaxime and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Nível de evidência: Moderate

Por que acontece

Antibacterial activity inhibits the live attenuated Salmonella strain, reducing immunogenicity.

O que fazer

Give live oral typhoid vaccine at least 3 days after the final cefotaxime dose, or vaccinate beforehand. Use the inactivated parenteral typhoid vaccine if timing cannot be separated.

O que perguntar ao farmacêutico

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Cefotaxime with Typhoid vaccine live?

MediHelp rates the interaction as major. Cefotaxime and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oral live typhoid vaccine depends on viable attenuated Salmonella Typhi colonizing the gut. Cefotaxime is active against Salmonella and may reduce vaccine viability and the resulting immunity.

How serious is the interaction between Cefotaxime and Typhoid vaccine live?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give live oral typhoid vaccine at least 3 days after the final cefotaxime dose, or vaccinate beforehand. Use the inactivated parenteral typhoid vaccine if timing cannot be separated.

What other medicines interact with Cefotaxime?

MediHelp also lists interactions of Cefotaxime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefotaxime page.

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