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Interações medicamentosas

Cefotaxime + Dexamethasone-tobramycin

Gravidade: Moderada

Cefotaxime and Dexamethasone-tobramycin: moderate interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

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Resumo

Cefotaxime with an aminoglycoside has been linked to additive kidney injury in some reports, particularly in patients with renal impairment or volume depletion.

O que esta interação significa em palavras simples

Cefotaxime and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Cefotaxime belongs to Anti Bacterial; Dexamethasone-tobramycin belongs to Anti Bacterial.

Nível de evidência: Low

Por que acontece

Possible additive nephrotoxicity; mechanism not firmly established.

O que fazer

Monitor serum creatinine and tobramycin concentrations, and adjust doses for renal function.

O que perguntar ao farmacêutico

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Cefotaxime with Dexamethasone-tobramycin?

MediHelp rates the interaction as moderate. Cefotaxime and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefotaxime with an aminoglycoside has been linked to additive kidney injury in some reports, particularly in patients with renal impairment or volume depletion.

How serious is the interaction between Cefotaxime and Dexamethasone-tobramycin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and tobramycin concentrations, and adjust doses for renal function.

What other medicines interact with Dexamethasone-tobramycin?

MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.

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