Interações medicamentosas
Amikacin + Zoledronic acid
Gravidade: Moderada
Amikacin and Zoledronic acid: moderate interaction.
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Resumo
Both zoledronic acid and aminoglycosides can lower serum calcium and magnesium, and both are nephrotoxic. Combined use may cause additive hypocalcemia and renal impairment.
O que esta interação significa em palavras simples
Amikacin and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Zoledronic acid belongs to Musculoskeletal.
Por que acontece
Additive hypocalcemia and hypomagnesemia, with overlapping nephrotoxicity from renal tubular injury.
O que fazer
Monitor serum calcium, magnesium and creatinine, and replace electrolytes as needed; keep aminoglycoside exposure short and monitor drug levels.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Zoledronic acid
- Bumetanide + Zoledronic acid Moderada
- Dichlorphenamide + Zoledronic acid Moderada
- Ethacrynic acid + Zoledronic acid Moderada
- Foscarnet + Zoledronic acid Moderada
- Gentamicin + Zoledronic acid Moderada
- Human parathyroid hormone recombinant + Zoledronic acid Moderada
Outras interações de Amikacin
- Amikacin + Cidofovir Contraindicada
- Adefovir + Amikacin Grave
- Amikacin + Amphotericin b Grave
- Amikacin + Amphotericin b deoxycholate Grave
- Amikacin + Atracurium Grave
- Amikacin + Bacitracin Grave
Perguntas frequentes
Can I take Amikacin with Zoledronic acid?
MediHelp rates the interaction as moderate. Amikacin and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both zoledronic acid and aminoglycosides can lower serum calcium and magnesium, and both are nephrotoxic. Combined use may cause additive hypocalcemia and renal impairment.
How serious is the interaction between Amikacin and Zoledronic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium, magnesium and creatinine, and replace electrolytes as needed; keep aminoglycoside exposure short and monitor drug levels.
What other medicines interact with Zoledronic acid?
MediHelp also lists interactions of Zoledronic acid with, for example, Bumetanide, Dichlorphenamide, Ethacrynic acid. The full list is on the Zoledronic acid page.
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