Referência de medicamentos
Zoledronic acid
Zoledronic acid is a medicine in the class musculoskeletal. It is used for glucocorticoid-induced osteoporosis.
- Classe do medicamento: Musculoskeletal
- Indicado para: glucocorticoid-induced osteoporosis
Última atualização
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O conteúdo clínico desta página está disponível apenas em inglês.
Pontos-chave
- Classe do medicamento
- Musculoskeletal
- Código ATC
- M05BA08
- Formas farmacêuticas comuns
- injeção, infusão
- Concentrações comuns
- 4 mg/5 ml, 5 mg/100 ml, 4 mg
- Interações conhecidas
- 19 (Moderada: 13 · Leve: 6)
- Nomes comerciais
- 37
- Países e mercados
- 5
Para que é usado
Como funciona
Bisphosphonate; inhibits bone resorption via actions on osteoclast activity, leading to indirect increase in bone density
Dose habitual em adultos (resumo da bula)
Hypercalcemia of Malignancy (Zometa): No more than 4 mg IV (infused over >15 minutes) once; may be repeated in 7 days
Gravidez e amamentação
- Gravidez
- Unsafe No human data. In rats it caused malformations and fetal loss at about 2 times human exposure. It is stored in bone for years, so a later pregnancy may also be exposed. EU label: contraindicated in pregnancy and not recommended in women who could conceive; US: stop when pregnancy is recognised.
- Amamentação
- Unknown No data on passage into milk; infant absorption is unlikely (LactMed). EU (Aclasta): contraindicated while breastfeeding; US oncology labels: do not breastfeed during and after treatment (bone retention); Reclast: weigh benefits. LactMed: prefer an alternative, especially with a newborn.
Efeitos adversos relatados
- Fatigue
- Vomiting
- Nausea
- Constipation
- Anemia
- Bone pain
Contraindicações
- Pregnancy
- All indications: Hypersensitivity, including rare cases of urticaria, angioedema, and anaphylactic reaction or shock
- Nononcologic uses: Hypocalcemia, severe renal impairment (CrCl <35 mL/min or evidence of acute renal impairment)
Quem deve ter cuidado
- Infuse over ≥15 minutes; faster infusion increases renal toxicity
- Increased risk of osteonecrosis of jaw (advise patients against dental work); reported predominantly in cancer patients treated with IV bisphosphonates
- Risk of osteonecrosis of the jaw may increase with duration of exposure to bisphosphonates
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Principais interações (19)
- Amikacin + Zoledronic acid Moderate
- Bumetanide + Zoledronic acid Moderate
- Dichlorphenamide + Zoledronic acid Moderate
- Ethacrynic acid + Zoledronic acid Moderate
- Foscarnet + Zoledronic acid Moderate
- Gentamicin + Zoledronic acid Moderate
- Human parathyroid hormone recombinant + Zoledronic acid Moderate
- Indomethacin + Zoledronic acid Moderate
- Sodium sulfate / ?magnesium sulfate / potassium chloride + Zoledronic acid Moderate
- Sodium sulfate / potassium sulfate / magnesium sulfate + Zoledronic acid Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Perguntas frequentes
What is Zoledronic acid used for?
Zoledronic acid is a medicine in the class musculoskeletal. It is used for Glucocorticoid-induced osteoporosis, Hypercalcemia of malignancy, Osteoporosis, Paget's disease.
What side effects have been reported with Zoledronic acid?
Fatigue, Vomiting, Nausea, Constipation, Anemia, Bone pain.
Can Zoledronic acid be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. No human data. In rats it caused malformations and fetal loss at about 2 times human exposure. It is stored in bone for years, so a later pregnancy may also be exposed. EU label: contraindicated in pregnancy and not recommended in women who could conceive; US: stop when pregnancy is recognised. Breastfeeding: Unknown. No data on passage into milk; infant absorption is unlikely (LactMed). EU (Aclasta): contraindicated while breastfeeding; US oncology labels: do not breastfeed during and after treatment (bone retention); Reclast: weigh benefits. LactMed: prefer an alternative, especially with a newborn.
What does Zoledronic acid interact with?
MediHelp lists 19 known interactions for Zoledronic acid. Moderate: 13 · Minor: 6. The most serious include Amikacin, Bumetanide, Dichlorphenamide.
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