Interações medicamentosas
Ethacrynic acid + Zoledronic acid
Gravidade: Moderada
Ethacrynic acid and Zoledronic acid: moderate interaction.
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Resumo
Zoledronic acid lowers serum calcium and loop diuretics such as ethacrynic acid increase urinary calcium loss. Together they may add to the risk of hypocalcemia, and ethacrynic acid can also add to electrolyte disturbances such as hypomagnesemia.
O que esta interação significa em palavras simples
Ethacrynic acid and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Zoledronic acid belongs to Musculoskeletal.
Por que acontece
Additive calcium lowering through inhibition of bone resorption (bisphosphonate) and increased renal calcium excretion (loop diuretic).
O que fazer
Correct hypocalcemia and vitamin D deficiency before zoledronic acid. Monitor serum calcium and magnesium after dosing and supplement calcium as needed.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Zoledronic acid
- Amikacin + Zoledronic acid Moderada
- Bumetanide + Zoledronic acid Moderada
- Dichlorphenamide + Zoledronic acid Moderada
- Foscarnet + Zoledronic acid Moderada
- Gentamicin + Zoledronic acid Moderada
- Human parathyroid hormone recombinant + Zoledronic acid Moderada
Outras interações de Ethacrynic acid
Perguntas frequentes
Can I take Ethacrynic acid with Zoledronic acid?
MediHelp rates the interaction as moderate. Ethacrynic acid and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zoledronic acid lowers serum calcium and loop diuretics such as ethacrynic acid increase urinary calcium loss. Together they may add to the risk of hypocalcemia, and ethacrynic acid can also add to electrolyte disturbances such as hypomagnesemia.
How serious is the interaction between Ethacrynic acid and Zoledronic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct hypocalcemia and vitamin D deficiency before zoledronic acid. Monitor serum calcium and magnesium after dosing and supplement calcium as needed.
What other medicines interact with Zoledronic acid?
MediHelp also lists interactions of Zoledronic acid with, for example, Amikacin, Bumetanide, Dichlorphenamide. The full list is on the Zoledronic acid page.
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