Interações medicamentosas
Amphotericin b liposomal + Melphalan
Gravidade: Moderada
Amphotericin b liposomal and Melphalan: moderate interaction.
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Resumo
Amphotericin B can cause nephrotoxicity and infusion reactions, and melphalan clearance depends partly on renal function, so toxicity may be heightened with combined use. The liposomal form is less nephrotoxic but the concern is not eliminated.
O que esta interação significa em palavras simples
Amphotericin b liposomal and Melphalan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b liposomal belongs to Anti Fungals; Melphalan belongs to Oncology.
Por que acontece
Possible additive renal toxicity; the mechanism of any wider interaction is not well established.
O que fazer
Monitor serum creatinine, electrolytes and blood counts, and watch for hypotension or bronchospasm during infusions. Adjust melphalan dose if renal function declines.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Melphalan
- Adenovirus types 4 and 7 live + Melphalan Contraindicada
- Bcg vaccine live + Melphalan Contraindicada
- Influenza virus vaccine quadrivalent intranasal + Melphalan Contraindicada
- Measles mumps and rubella vaccine live + Melphalan Contraindicada
- Measles mumps and rubella vaccine + Melphalan Contraindicada
- Measles mumps rubella and varicella vaccine live + Melphalan Contraindicada
Outras interações de Amphotericin b liposomal
- Amlodipine-benazepril + Amphotericin b liposomal Moderada
- Amphotericin b liposomal + Benazepril Moderada
- Amphotericin b liposomal + Captopril-hydrochlorothiazide Moderada
- Amphotericin b liposomal + Deflazacort Moderada
- Amphotericin b liposomal + Dichlorphenamide Moderada
- Amphotericin b liposomal + Ifosfamide Moderada
Perguntas frequentes
Can I take Amphotericin b liposomal with Melphalan?
MediHelp rates the interaction as moderate. Amphotericin b liposomal and Melphalan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B can cause nephrotoxicity and infusion reactions, and melphalan clearance depends partly on renal function, so toxicity may be heightened with combined use. The liposomal form is less nephrotoxic but the concern is not eliminated.
How serious is the interaction between Amphotericin b liposomal and Melphalan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, electrolytes and blood counts, and watch for hypotension or bronchospasm during infusions. Adjust melphalan dose if renal function declines.
What other medicines interact with Melphalan?
MediHelp also lists interactions of Melphalan with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Melphalan page.
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