Interações medicamentosas
Apalutamide + Tofacitinib
Gravidade: Grave
Apalutamide and Tofacitinib: major interaction.
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Resumo
Apalutamide is a strong inducer of CYP3A4 and CYP2C19, the enzymes that clear tofacitinib. Exposure to tofacitinib may fall and its therapeutic effect may be reduced.
O que esta interação significa em palavras simples
Apalutamide and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Tofacitinib belongs to Musculoskeletal.
Por que acontece
Induction of CYP3A4 and CYP2C19 increases the metabolism of tofacitinib.
O que fazer
Avoid the combination where possible and choose an alternative. If it cannot be avoided, monitor for loss of tofacitinib efficacy and adjust therapy accordingly.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Tofacitinib
- Baricitinib + Tofacitinib Contraindicada
- Cladribine + Tofacitinib Contraindicada
- Tofacitinib + Upadacitinib Contraindicada
- Abatacept + Tofacitinib Grave
- Anti-thymocyte + Tofacitinib Grave
- Antithymocyte globulin equine + Tofacitinib Grave
Outras interações de Apalutamide
- Apalutamide + Cabotegravir Contraindicada
- Apalutamide + Cobicistat Contraindicada
- Apalutamide + Doravirine Contraindicada
- Apalutamide + Elbasvir / grazoprevir Contraindicada
- Apalutamide + Ensitrelvir Contraindicada
- Apalutamide + Fostemsavir Contraindicada
Perguntas frequentes
Can I take Apalutamide with Tofacitinib?
MediHelp rates the interaction as major. Apalutamide and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide is a strong inducer of CYP3A4 and CYP2C19, the enzymes that clear tofacitinib. Exposure to tofacitinib may fall and its therapeutic effect may be reduced.
How serious is the interaction between Apalutamide and Tofacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an alternative. If it cannot be avoided, monitor for loss of tofacitinib efficacy and adjust therapy accordingly.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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