Interações medicamentosas
Apomorphine + Methyldopa
Gravidade: Moderada
Apomorphine and Methyldopa: moderate interaction.
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Resumo
Both apomorphine and methyldopa can cause hypotension, and apomorphine is notable for orthostatic hypotension and syncope. Combined use may worsen low blood pressure and dizziness, particularly during apomorphine initiation.
O que esta interação significa em palavras simples
Apomorphine and Methyldopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Methyldopa belongs to Cardiovascular.
Por que acontece
Additive hypotensive effects of dopamine agonism and methyldopa's central alpha-2 mediated sympathetic inhibition.
O que fazer
Monitor supine and standing blood pressure when starting apomorphine and consider reducing antihypertensive doses if hypotension occurs.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Methyldopa
- Methyldopa + Tranylcypromine Contraindicada
- Iobenguane i + Methyldopa Grave
- Lofexidine + Methyldopa Grave
- Methyldopa + Pexidartinib Grave
- Methyldopa + Pretomanid Grave
- Methyldopa + Thioridazine Grave
Outras interações de Apomorphine
- Alosetron + Apomorphine Contraindicada
- Apomorphine + Cisapride Contraindicada
- Apomorphine + Dolasetron Contraindicada
- Apomorphine + Granisetron Contraindicada
- Apomorphine + Netupitant-palonosetron Contraindicada
- Apomorphine + Ondansetron Contraindicada
Perguntas frequentes
Can I take Apomorphine with Methyldopa?
MediHelp rates the interaction as moderate. Apomorphine and Methyldopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both apomorphine and methyldopa can cause hypotension, and apomorphine is notable for orthostatic hypotension and syncope. Combined use may worsen low blood pressure and dizziness, particularly during apomorphine initiation.
How serious is the interaction between Apomorphine and Methyldopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure when starting apomorphine and consider reducing antihypertensive doses if hypotension occurs.
What other medicines interact with Methyldopa?
MediHelp also lists interactions of Methyldopa with, for example, Tranylcypromine, Iobenguane i, Lofexidine. The full list is on the Methyldopa page.
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