Drug interactions
Apomorphine + Methyldopa
Severity: Moderate
Apomorphine and Methyldopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both apomorphine and methyldopa can cause hypotension, and apomorphine is notable for orthostatic hypotension and syncope. Combined use may worsen low blood pressure and dizziness, particularly during apomorphine initiation.
What this interaction means in plain words
Apomorphine and Methyldopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Methyldopa belongs to Cardiovascular.
Why it happens
Additive hypotensive effects of dopamine agonism and methyldopa's central alpha-2 mediated sympathetic inhibition.
What to do
Monitor supine and standing blood pressure when starting apomorphine and consider reducing antihypertensive doses if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methyldopa
- Methyldopa + Tranylcypromine Contraindicated
- Iobenguane i + Methyldopa Major
- Lofexidine + Methyldopa Major
- Methyldopa + Pexidartinib Major
- Methyldopa + Pretomanid Major
- Methyldopa + Thioridazine Major
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Methyldopa?
MediHelp rates the interaction as moderate. Apomorphine and Methyldopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both apomorphine and methyldopa can cause hypotension, and apomorphine is notable for orthostatic hypotension and syncope. Combined use may worsen low blood pressure and dizziness, particularly during apomorphine initiation.
How serious is the interaction between Apomorphine and Methyldopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure when starting apomorphine and consider reducing antihypertensive doses if hypotension occurs.
What other medicines interact with Methyldopa?
MediHelp also lists interactions of Methyldopa with, for example, Tranylcypromine, Iobenguane i, Lofexidine. The full list is on the Methyldopa page.
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