Interações medicamentosas
Arsenic trioxide + Indacaterol-glycopyrronium
Gravidade: Grave
Arsenic trioxide and Indacaterol-glycopyrronium: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Arsenic trioxide markedly prolongs the QT interval and has caused torsade de pointes. Adding indacaterol, which can influence repolarization, heart rate and potassium levels, may add to the arrhythmic risk.
O que esta interação significa em palavras simples
Arsenic trioxide and Indacaterol-glycopyrronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Arsenic trioxide belongs to Oncology; Indacaterol-glycopyrronium belongs to Respiratory.
Por que acontece
Additive QT prolongation, with beta2-agonist induced hypokalemia worsening arrhythmia susceptibility.
O que fazer
Prefer alternative bronchodilators during arsenic trioxide therapy if feasible. If combined, keep potassium and magnesium replete and monitor ECG regularly.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Arsenic trioxide e Indacaterol-glycopyrronium, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Indacaterol-glycopyrronium
Outras interações de Arsenic trioxide
- Amiodarone + Arsenic trioxide Contraindicada
- Amisulpride + Arsenic trioxide Contraindicada
- Arsenic trioxide + Clomipramine Contraindicada
- Arsenic trioxide + Dronedarone Contraindicada
- Arsenic trioxide + Fluphenazine Contraindicada
- Arsenic trioxide + Gemifloxacin Contraindicada
Perguntas frequentes
Can I take Arsenic trioxide with Indacaterol-glycopyrronium?
MediHelp rates the interaction as major. Arsenic trioxide and Indacaterol-glycopyrronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Arsenic trioxide markedly prolongs the QT interval and has caused torsade de pointes. Adding indacaterol, which can influence repolarization, heart rate and potassium levels, may add to the arrhythmic risk.
How serious is the interaction between Arsenic trioxide and Indacaterol-glycopyrronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer alternative bronchodilators during arsenic trioxide therapy if feasible. If combined, keep potassium and magnesium replete and monitor ECG regularly.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Betaxolol. The full list is on the Indacaterol-glycopyrronium page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
