Interações medicamentosas
Atazanavir + Simvastatin
Gravidade: Contraindicada
Atazanavir and Simvastatin: contraindicated interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Atazanavir, usually boosted with ritonavir or cobicistat, strongly inhibits CYP3A4 and greatly increases simvastatin exposure. This raises the risk of myopathy and rhabdomyolysis, and simvastatin labeling contraindicates it.
O que esta interação significa em palavras simples
Atazanavir and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Atazanavir belongs to Anti Virals; Simvastatin belongs to Cardiovascular.
Por que acontece
Inhibition of CYP3A4-mediated simvastatin metabolism raises simvastatin and its active acid levels.
O que fazer
Do not combine; switch to a statin with less CYP3A4 dependence such as pravastatin or rosuvastatin, with dose limits as appropriate.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Atazanavir e Simvastatin, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Simvastatin
- Clarithromycin + Simvastatin Contraindicada
- Cobicistat + Simvastatin Contraindicada
- Cyclosporine + Simvastatin Contraindicada
- Cyclosporin + Simvastatin Contraindicada
- Danazol + Simvastatin Contraindicada
- Darunavir + Simvastatin Contraindicada
Outras interações de Atazanavir
- Alfuzosin + Atazanavir Contraindicada
- Atazanavir + Avanafil Contraindicada
- Atazanavir + Dronedarone Contraindicada
- Atazanavir + Eletriptan Contraindicada
- Atazanavir + Eplerenone Contraindicada
- Atazanavir + Ergotamine Contraindicada
Perguntas frequentes
Can I take Atazanavir with Simvastatin?
MediHelp rates the interaction as contraindicated. Atazanavir and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Atazanavir, usually boosted with ritonavir or cobicistat, strongly inhibits CYP3A4 and greatly increases simvastatin exposure. This raises the risk of myopathy and rhabdomyolysis, and simvastatin labeling contraindicates it.
How serious is the interaction between Atazanavir and Simvastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; switch to a statin with less CYP3A4 dependence such as pravastatin or rosuvastatin, with dose limits as appropriate.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Simvastatin page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
