Interações medicamentosas
Darunavir + Simvastatin
Gravidade: Contraindicada
Darunavir and Simvastatin: contraindicated interaction.
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Resumo
Darunavir, usually given with ritonavir or cobicistat, substantially raises simvastatin concentrations and the risk of rhabdomyolysis. The combination is contraindicated in labeling.
O que esta interação significa em palavras simples
Darunavir and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Darunavir belongs to Anti Virals; Simvastatin belongs to Cardiovascular.
Por que acontece
Darunavir and its pharmacokinetic booster inhibit CYP3A4, blocking first-pass and hepatic metabolism of simvastatin.
O que fazer
Do not co-administer; stop simvastatin during darunavir therapy and use an alternative such as pravastatin or low-dose atorvastatin or rosuvastatin with monitoring.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Simvastatin
- Atazanavir + Simvastatin Contraindicada
- Clarithromycin + Simvastatin Contraindicada
- Cobicistat + Simvastatin Contraindicada
- Cyclosporine + Simvastatin Contraindicada
- Cyclosporin + Simvastatin Contraindicada
- Danazol + Simvastatin Contraindicada
Outras interações de Darunavir
- Alfuzosin + Darunavir Contraindicada
- Avanafil + Darunavir Contraindicada
- Darunavir + Dronedarone Contraindicada
- Darunavir + Eletriptan Contraindicada
- Darunavir + Ergotamine Contraindicada
- Darunavir + Flibanserin Contraindicada
Perguntas frequentes
Can I take Darunavir with Simvastatin?
MediHelp rates the interaction as contraindicated. Darunavir and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Darunavir, usually given with ritonavir or cobicistat, substantially raises simvastatin concentrations and the risk of rhabdomyolysis. The combination is contraindicated in labeling.
How serious is the interaction between Darunavir and Simvastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; stop simvastatin during darunavir therapy and use an alternative such as pravastatin or low-dose atorvastatin or rosuvastatin with monitoring.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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