Interações medicamentosas
Cyclosporin + Simvastatin
Gravidade: Contraindicada
Cyclosporin and Simvastatin: contraindicated interaction.
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Resumo
Cyclosporine inhibits CYP3A4 and OATP1B1 and markedly raises simvastatin acid exposure. The risk of myopathy and rhabdomyolysis is high.
O que esta interação significa em palavras simples
Cyclosporin and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cyclosporin belongs to Miscellaneous; Simvastatin belongs to Cardiovascular.
Por que acontece
CYP3A4 and OATP1B1 inhibition raises simvastatin exposure
O que fazer
Contraindicated by labelling; use a different statin (for example pravastatin or rosuvastatin at a limited dose).
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicada
- Aliskiren + Cyclosporin Contraindicada
- Bcg vaccine live + Cyclosporin Contraindicada
- Bosentan + Cyclosporin Contraindicada
- Cidofovir + Cyclosporin Contraindicada
- Cyclosporin + Dengue vaccine Contraindicada
Outras interações de Simvastatin
- Atazanavir + Simvastatin Contraindicada
- Clarithromycin + Simvastatin Contraindicada
- Cobicistat + Simvastatin Contraindicada
- Cyclosporine + Simvastatin Contraindicada
- Danazol + Simvastatin Contraindicada
- Darunavir + Simvastatin Contraindicada
Perguntas frequentes
Can I take Cyclosporin with Simvastatin?
MediHelp rates the interaction as contraindicated. Cyclosporin and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cyclosporine inhibits CYP3A4 and OATP1B1 and markedly raises simvastatin acid exposure. The risk of myopathy and rhabdomyolysis is high.
How serious is the interaction between Cyclosporin and Simvastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated by labelling; use a different statin (for example pravastatin or rosuvastatin at a limited dose).
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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