Interações medicamentosas
Danazol + Simvastatin
Gravidade: Contraindicada
Danazol and Simvastatin: contraindicated interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Danazol increases simvastatin exposure and has been associated with myopathy and rhabdomyolysis when combined with it. The labeling lists this pairing as contraindicated.
O que esta interação significa em palavras simples
Danazol and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Danazol inhibits CYP3A4 and so reduces the metabolism of simvastatin, increasing systemic exposure.
O que fazer
Avoid the combination; if danazol is required, stop simvastatin or switch to a statin not dependent on CYP3A4. Report any unexplained muscle pain or weakness promptly.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Simvastatin
- Atazanavir + Simvastatin Contraindicada
- Clarithromycin + Simvastatin Contraindicada
- Cobicistat + Simvastatin Contraindicada
- Cyclosporine + Simvastatin Contraindicada
- Cyclosporin + Simvastatin Contraindicada
- Darunavir + Simvastatin Contraindicada
Perguntas frequentes
Can I take Danazol with Simvastatin?
MediHelp rates the interaction as contraindicated. Danazol and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Danazol increases simvastatin exposure and has been associated with myopathy and rhabdomyolysis when combined with it. The labeling lists this pairing as contraindicated.
How serious is the interaction between Danazol and Simvastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if danazol is required, stop simvastatin or switch to a statin not dependent on CYP3A4. Report any unexplained muscle pain or weakness promptly.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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