Interações medicamentosas
Axicabtagene ciloleucel + Tofacitinib
Gravidade: Grave
Axicabtagene ciloleucel and Tofacitinib: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Tofacitinib's immunosuppression may impair CAR-T expansion and efficacy, and adds to the infection risk that follows lymphodepletion and CAR-T therapy. Prior use of immunosuppressants is generally minimized around infusion.
O que esta interação significa em palavras simples
Axicabtagene ciloleucel and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Axicabtagene ciloleucel belongs to Oncology; Tofacitinib belongs to Musculoskeletal.
Por que acontece
JAK inhibition suppresses T-cell signalling and may reduce CAR-T activity, with additive immunosuppression.
O que fazer
Hold tofacitinib around leukapheresis and infusion as advised by the treating team. Monitor closely for infection.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Tofacitinib
- Baricitinib + Tofacitinib Contraindicada
- Cladribine + Tofacitinib Contraindicada
- Tofacitinib + Upadacitinib Contraindicada
- Abatacept + Tofacitinib Grave
- Anti-thymocyte + Tofacitinib Grave
- Antithymocyte globulin equine + Tofacitinib Grave
Outras interações de Axicabtagene ciloleucel
Perguntas frequentes
Can I take Axicabtagene ciloleucel with Tofacitinib?
MediHelp rates the interaction as major. Axicabtagene ciloleucel and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tofacitinib's immunosuppression may impair CAR-T expansion and efficacy, and adds to the infection risk that follows lymphodepletion and CAR-T therapy. Prior use of immunosuppressants is generally minimized around infusion.
How serious is the interaction between Axicabtagene ciloleucel and Tofacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold tofacitinib around leukapheresis and infusion as advised by the treating team. Monitor closely for infection.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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