Interações medicamentosas
Aztreonam + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Gravidade: Moderada
Aztreonam and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Sodium picosulfate is a prodrug that needs colonic bacteria to convert it into its active laxative form. Antibacterial agents that reduce colonic flora could weaken the bowel-cleansing effect before colonoscopy. Aztreonam has activity against gram-negative aerobes, and the label for the preparation warns about antibiotic use.
O que esta interação significa em palavras simples
Aztreonam and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Antibiotic-induced reduction of colonic bacteria impairs conversion of sodium picosulfate to its active metabolite.
O que fazer
Be alert to inadequate bowel preparation in patients receiving the antibiotic and consider extra preparation or rescheduling if cleansing is poor. Where clinically possible, avoid starting the antibiotic course during the preparation window.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Aztreonam
- Aztreonam + Cefoxitin Moderada
- Aztreonam + Cholera vaccine Moderada
- Aztreonam + Microbiota Moderada
- Aztreonam + Typhoid vaccine live Moderada
- Amikacin + Aztreonam Leve
- Amoxicillin-clavulanic acid + Aztreonam Leve
Perguntas frequentes
Can I take Aztreonam with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Aztreonam and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium picosulfate is a prodrug that needs colonic bacteria to convert it into its active laxative form. Antibacterial agents that reduce colonic flora could weaken the bowel-cleansing effect before colonoscopy. Aztreonam has activity against gram-negative aerobes, and the label for the preparation warns about antibiotic use.
How serious is the interaction between Aztreonam and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be alert to inadequate bowel preparation in patients receiving the antibiotic and consider extra preparation or rescheduling if cleansing is poor. Where clinically possible, avoid starting the antibiotic course during the preparation window.
What other medicines interact with Aztreonam?
MediHelp also lists interactions of Aztreonam with, for example, Cefoxitin, Cholera vaccine, Microbiota. The full list is on the Aztreonam page.
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