Interações medicamentosas
Balsalazide + Vadadustat
Gravidade: Moderada
Balsalazide and Vadadustat: moderate interaction.
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Resumo
Vadadustat is an OAT1/OAT3 substrate, and balsalazide or its salicylate metabolites may inhibit these transporters. Vadadustat exposure may rise, causing an excessive hemoglobin increase and more adverse reactions.
O que esta interação significa em palavras simples
Balsalazide and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Balsalazide belongs to Gastrointestinal Tract; Vadadustat belongs to Endocrine.
Por que acontece
Inhibition of renal OAT1/OAT3 transport reduces vadadustat clearance.
O que fazer
Monitor hemoglobin closely and adjust vadadustat dose according to labeling if the rise is too rapid.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Balsalazide
Outras interações de Vadadustat
- Atorvastatin + Vadadustat Moderada
- Baricitinib + Vadadustat Moderada
- Benzathine penicillin g + Vadadustat Moderada
- Calcium carbonate + Vadadustat Moderada
- Calcium + Vadadustat Moderada
- Cladribine + Vadadustat Moderada
Perguntas frequentes
Can I take Balsalazide with Vadadustat?
MediHelp rates the interaction as moderate. Balsalazide and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat is an OAT1/OAT3 substrate, and balsalazide or its salicylate metabolites may inhibit these transporters. Vadadustat exposure may rise, causing an excessive hemoglobin increase and more adverse reactions.
How serious is the interaction between Balsalazide and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin closely and adjust vadadustat dose according to labeling if the rise is too rapid.
What other medicines interact with Balsalazide?
MediHelp also lists interactions of Balsalazide with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Balsalazide page.
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