Interações medicamentosas
Benzathine penicillin g + Vadadustat
Gravidade: Moderada
Benzathine penicillin g and Vadadustat: moderate interaction.
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Resumo
Penicillin G can inhibit the renal transporters OAT1 and OAT3, which are involved in vadadustat elimination. Vadadustat exposure may therefore increase, raising the risk of an excessive hemoglobin rise and adverse effects. The clinical significance is likely small with benzathine penicillin because of its low and prolonged serum levels.
O que esta interação significa em palavras simples
Benzathine penicillin g and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benzathine penicillin g belongs to Anti Bacterial; Vadadustat belongs to Endocrine.
Por que acontece
Penicillin G competes for OAT1/OAT3-mediated renal transport, which may reduce vadadustat clearance.
O que fazer
Monitor hemoglobin response and for vadadustat adverse reactions during concurrent use. Reduce the vadadustat dose if hemoglobin rises too rapidly.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Benzathine penicillin g
- Benzathine penicillin g + Cholera vaccine Moderada
- Benzathine penicillin g + Microbiota Moderada
- Benzathine penicillin g + Omadacycline Moderada
- Benzathine penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderada
- Amifampridine + Benzathine penicillin g Leve
- Baricitinib + Benzathine penicillin g Leve
Outras interações de Vadadustat
- Atorvastatin + Vadadustat Moderada
- Balsalazide + Vadadustat Moderada
- Baricitinib + Vadadustat Moderada
- Calcium carbonate + Vadadustat Moderada
- Calcium + Vadadustat Moderada
- Cladribine + Vadadustat Moderada
Perguntas frequentes
Can I take Benzathine penicillin g with Vadadustat?
MediHelp rates the interaction as moderate. Benzathine penicillin g and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Penicillin G can inhibit the renal transporters OAT1 and OAT3, which are involved in vadadustat elimination. Vadadustat exposure may therefore increase, raising the risk of an excessive hemoglobin rise and adverse effects. The clinical significance is likely small with benzathine penicillin because of its low and prolonged serum levels.
How serious is the interaction between Benzathine penicillin g and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin response and for vadadustat adverse reactions during concurrent use. Reduce the vadadustat dose if hemoglobin rises too rapidly.
What other medicines interact with Benzathine penicillin g?
MediHelp also lists interactions of Benzathine penicillin g with, for example, Cholera vaccine, Microbiota, Omadacycline. The full list is on the Benzathine penicillin g page.
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