Interações medicamentosas
Baricitinib + Vadadustat
Gravidade: Moderada
Baricitinib and Vadadustat: moderate interaction.
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Resumo
Vadadustat inhibits the organic anion transporter 3 (OAT3), which is a major route of renal elimination for baricitinib. Co-administration can raise baricitinib exposure and may increase dose-related adverse effects such as infection, cytopenias and lipid changes.
O que esta interação significa em palavras simples
Baricitinib and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baricitinib belongs to Musculoskeletal; Vadadustat belongs to Endocrine.
Por que acontece
Vadadustat inhibits OAT3-mediated renal tubular secretion of baricitinib, reducing its clearance.
O que fazer
Monitor for baricitinib adverse effects, including infections and blood counts. Consider baricitinib dose reduction according to its labeling for OAT3 inhibitors.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicada
- Baricitinib + Bcg vaccine live Contraindicada
- Baricitinib + Tofacitinib Contraindicada
- Baricitinib + Upadacitinib Contraindicada
- Abatacept + Baricitinib Grave
- Adalimumab + Baricitinib Grave
Outras interações de Vadadustat
- Atorvastatin + Vadadustat Moderada
- Balsalazide + Vadadustat Moderada
- Benzathine penicillin g + Vadadustat Moderada
- Calcium carbonate + Vadadustat Moderada
- Calcium + Vadadustat Moderada
- Cladribine + Vadadustat Moderada
Perguntas frequentes
Can I take Baricitinib with Vadadustat?
MediHelp rates the interaction as moderate. Baricitinib and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat inhibits the organic anion transporter 3 (OAT3), which is a major route of renal elimination for baricitinib. Co-administration can raise baricitinib exposure and may increase dose-related adverse effects such as infection, cytopenias and lipid changes.
How serious is the interaction between Baricitinib and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for baricitinib adverse effects, including infections and blood counts. Consider baricitinib dose reduction according to its labeling for OAT3 inhibitors.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.
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