Interações medicamentosas
Baricitinib + Benzathine penicillin g
Gravidade: Leve
Baricitinib and Benzathine penicillin g: minor interaction.
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Resumo
Penicillins can inhibit OAT3, a transporter involved in baricitinib renal elimination, so baricitinib exposure may rise. Labeling advises against strong OAT3 inhibitors such as probenecid, but penicillin G is a much weaker inhibitor and benzathine penicillin gives low sustained levels, so the effect is likely small.
O que esta interação significa em palavras simples
Baricitinib and Benzathine penicillin g have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Baricitinib belongs to Musculoskeletal; Benzathine penicillin g belongs to Anti Bacterial.
Por que acontece
Possible weak OAT3 inhibition reducing renal tubular secretion of baricitinib.
O que fazer
No dose change is generally needed; monitor for baricitinib adverse effects such as infection and cytopenias as usual.
O que perguntar ao farmacêutico
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Outras interações de Benzathine penicillin g
- Benzathine penicillin g + Cholera vaccine Moderada
- Benzathine penicillin g + Microbiota Moderada
- Benzathine penicillin g + Omadacycline Moderada
- Benzathine penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderada
- Benzathine penicillin g + Vadadustat Moderada
- Amifampridine + Benzathine penicillin g Leve
Outras interações de Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicada
- Baricitinib + Bcg vaccine live Contraindicada
- Baricitinib + Tofacitinib Contraindicada
- Baricitinib + Upadacitinib Contraindicada
- Abatacept + Baricitinib Grave
- Adalimumab + Baricitinib Grave
Perguntas frequentes
Can I take Baricitinib with Benzathine penicillin g?
MediHelp rates the interaction as minor. Baricitinib and Benzathine penicillin g have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Penicillins can inhibit OAT3, a transporter involved in baricitinib renal elimination, so baricitinib exposure may rise. Labeling advises against strong OAT3 inhibitors such as probenecid, but penicillin G is a much weaker inhibitor and benzathine penicillin gives low sustained levels, so the effect is likely small.
How serious is the interaction between Baricitinib and Benzathine penicillin g?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for baricitinib adverse effects such as infection and cytopenias as usual.
What other medicines interact with Benzathine penicillin g?
MediHelp also lists interactions of Benzathine penicillin g with, for example, Cholera vaccine, Microbiota, Omadacycline. The full list is on the Benzathine penicillin g page.
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