Interações medicamentosas
Bevacizumab + Sunitinib
Gravidade: Grave
Bevacizumab and Sunitinib: major interaction.
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Resumo
Combining these two anti-angiogenic agents has led to microangiopathic hemolytic anemia in patients with metastatic renal cell carcinoma. Hypertension and thrombocytopenia have also been seen, which makes the combination poorly tolerated.
O que esta interação significa em palavras simples
Bevacizumab and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bevacizumab belongs to Oncology; Sunitinib belongs to Oncology.
Por que acontece
Combined inhibition of VEGF signalling at the ligand and receptor tyrosine kinase level causing endothelial injury and microangiopathy; exact mechanism is not fully defined.
O que fazer
Avoid concurrent use. If microangiopathic hemolytic anemia is suspected, check hemoglobin, platelets, LDH, haptoglobin and a blood smear, and stop the drugs.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Bevacizumab
- Bevacizumab + Daunorubicin Moderada
- Bevacizumab + Dengue vaccine Moderada
- Bevacizumab + Doxorubicin Moderada
- Bevacizumab + Doxorubicin liposomal Moderada
- Bevacizumab + Efgartigimod / hyaluronidase sc Moderada
- Bevacizumab + Efgartigimod alfa Moderada
Outras interações de Sunitinib
- Adagrasib + Sunitinib Grave
- Amiodarone + Sunitinib Grave
- Amisulpride + Sunitinib Grave
- Anagrelide + Sunitinib Grave
- Apalutamide + Sunitinib Grave
- Arsenic trioxide + Sunitinib Grave
Perguntas frequentes
Can I take Bevacizumab with Sunitinib?
MediHelp rates the interaction as major. Bevacizumab and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining these two anti-angiogenic agents has led to microangiopathic hemolytic anemia in patients with metastatic renal cell carcinoma. Hypertension and thrombocytopenia have also been seen, which makes the combination poorly tolerated.
How serious is the interaction between Bevacizumab and Sunitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. If microangiopathic hemolytic anemia is suspected, check hemoglobin, platelets, LDH, haptoglobin and a blood smear, and stop the drugs.
What other medicines interact with Bevacizumab?
MediHelp also lists interactions of Bevacizumab with, for example, Daunorubicin, Dengue vaccine, Doxorubicin. The full list is on the Bevacizumab page.
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