Interações medicamentosas
Bevacizumab + Doxorubicin
Gravidade: Moderada
Bevacizumab and Doxorubicin: moderate interaction.
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Resumo
Both agents can impair cardiac function, and bevacizumab may add to anthracycline-related heart failure and left ventricular dysfunction. Bevacizumab also causes hypertension, which adds to cardiac strain. The risk is greater with higher cumulative anthracycline doses or prior cardiac disease.
O que esta interação significa em palavras simples
Bevacizumab and Doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bevacizumab belongs to Oncology; Doxorubicin belongs to Oncology.
Por que acontece
Additive cardiotoxicity through anthracycline myocardial injury and VEGF inhibition with associated hypertension.
O que fazer
Assess baseline left ventricular ejection fraction and repeat periodically during treatment. Control blood pressure and track the cumulative doxorubicin dose.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Doxorubicin
Outras interações de Bevacizumab
- Bevacizumab + Sunitinib Grave
- Bevacizumab + Daunorubicin Moderada
- Bevacizumab + Dengue vaccine Moderada
- Bevacizumab + Doxorubicin liposomal Moderada
- Bevacizumab + Efgartigimod / hyaluronidase sc Moderada
- Bevacizumab + Efgartigimod alfa Moderada
Perguntas frequentes
Can I take Bevacizumab with Doxorubicin?
MediHelp rates the interaction as moderate. Bevacizumab and Doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can impair cardiac function, and bevacizumab may add to anthracycline-related heart failure and left ventricular dysfunction. Bevacizumab also causes hypertension, which adds to cardiac strain. The risk is greater with higher cumulative anthracycline doses or prior cardiac disease.
How serious is the interaction between Bevacizumab and Doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess baseline left ventricular ejection fraction and repeat periodically during treatment. Control blood pressure and track the cumulative doxorubicin dose.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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