Interações medicamentosas
Bleomycin + Brentuximab vedotin
Gravidade: Contraindicada
Bleomycin and Brentuximab vedotin: contraindicated interaction.
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Resumo
Concomitant use with bleomycin led to excess pulmonary toxicity in Hodgkin lymphoma patients, and this combination is contraindicated in the brentuximab labeling. Patients may develop pneumonitis or respiratory failure.
O que esta interação significa em palavras simples
Bleomycin and Brentuximab vedotin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bleomycin belongs to Oncology; Brentuximab vedotin belongs to Oncology.
Por que acontece
Additive or synergistic lung injury; the exact mechanism is not fully established.
O que fazer
Do not combine; omit bleomycin from regimens containing brentuximab vedotin (for example AVD with brentuximab). Evaluate any new cough or dyspnea promptly.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Bleomycin
- Adenovirus types 4 and 7 live + Bleomycin Contraindicada
- Bleomycin + Brentuximab Contraindicada
- Bleomycin + Dengue vaccine Grave
- Bleomycin + Trastuzumab deruxtecan Grave
- Bleomycin + Cholera vaccine Moderada
- Bleomycin + Ethotoin Moderada
Outras interações de Brentuximab vedotin
- Brentuximab vedotin + Siponimod Grave
- Apalutamide + Brentuximab vedotin Moderada
- Brentuximab vedotin + Clarithromycin Moderada
- Brentuximab vedotin + Imatinib Moderada
- Brentuximab vedotin + Isoniazid Moderada
- Brentuximab vedotin + Itraconazole Moderada
Perguntas frequentes
Can I take Bleomycin with Brentuximab vedotin?
MediHelp rates the interaction as contraindicated. Bleomycin and Brentuximab vedotin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Concomitant use with bleomycin led to excess pulmonary toxicity in Hodgkin lymphoma patients, and this combination is contraindicated in the brentuximab labeling. Patients may develop pneumonitis or respiratory failure.
How serious is the interaction between Bleomycin and Brentuximab vedotin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; omit bleomycin from regimens containing brentuximab vedotin (for example AVD with brentuximab). Evaluate any new cough or dyspnea promptly.
What other medicines interact with Bleomycin?
MediHelp also lists interactions of Bleomycin with, for example, Adenovirus types 4 and 7 live, Brentuximab, Dengue vaccine. The full list is on the Bleomycin page.
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