Interações medicamentosas
Brentuximab vedotin + Clarithromycin
Gravidade: Moderada
Brentuximab vedotin and Clarithromycin: moderate interaction.
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Resumo
Strong CYP3A4 inhibition by clarithromycin can increase exposure to free MMAE, the cytotoxic component released from brentuximab vedotin. This may increase the risk of neutropenia and other toxicities.
O que esta interação significa em palavras simples
Brentuximab vedotin and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab vedotin belongs to Oncology; Clarithromycin belongs to Anti Bacterial.
Por que acontece
Clarithromycin inhibits CYP3A4, the main enzyme metabolizing MMAE released from the antibody-drug conjugate.
O que fazer
Monitor closely for neutropenia and other adverse reactions. Consider an alternative antibiotic that does not inhibit CYP3A4.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Clarithromycin
- Astemizole + Clarithromycin Contraindicada
- Avanafil + Clarithromycin Contraindicada
- Cisapride + Clarithromycin Contraindicada
- Clarithromycin + Colchicine Contraindicada
- Clarithromycin + Conivaptan Contraindicada
- Clarithromycin + Dihydroergotamine Contraindicada
Outras interações de Brentuximab vedotin
- Bleomycin + Brentuximab vedotin Contraindicada
- Brentuximab vedotin + Siponimod Grave
- Apalutamide + Brentuximab vedotin Moderada
- Brentuximab vedotin + Imatinib Moderada
- Brentuximab vedotin + Isoniazid Moderada
- Brentuximab vedotin + Itraconazole Moderada
Perguntas frequentes
Can I take Brentuximab vedotin with Clarithromycin?
MediHelp rates the interaction as moderate. Brentuximab vedotin and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Strong CYP3A4 inhibition by clarithromycin can increase exposure to free MMAE, the cytotoxic component released from brentuximab vedotin. This may increase the risk of neutropenia and other toxicities.
How serious is the interaction between Brentuximab vedotin and Clarithromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for neutropenia and other adverse reactions. Consider an alternative antibiotic that does not inhibit CYP3A4.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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