Interações medicamentosas
Brentuximab vedotin + Isoniazid
Gravidade: Moderada
Brentuximab vedotin and Isoniazid: moderate interaction.
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Resumo
The cytotoxic component of brentuximab vedotin, MMAE, is metabolized by CYP3A4, so CYP3A4 inhibitors can raise its exposure and the risk of neutropenia. Isoniazid is only a weak inhibitor, so any effect is likely modest. Isoniazid also adds neuropathy and hepatotoxicity risk.
O que esta interação significa em palavras simples
Brentuximab vedotin and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab vedotin belongs to Oncology; Isoniazid belongs to Anti Bacterial.
Por que acontece
Possible weak CYP3A4 inhibition by isoniazid increasing MMAE exposure, with additive neurotoxicity.
O que fazer
Monitor blood counts for neutropenia and for peripheral neuropathy. Give pyridoxine as per isoniazid practice.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Isoniazid
Outras interações de Brentuximab vedotin
- Bleomycin + Brentuximab vedotin Contraindicada
- Brentuximab vedotin + Siponimod Grave
- Apalutamide + Brentuximab vedotin Moderada
- Brentuximab vedotin + Clarithromycin Moderada
- Brentuximab vedotin + Imatinib Moderada
- Brentuximab vedotin + Itraconazole Moderada
Perguntas frequentes
Can I take Brentuximab vedotin with Isoniazid?
MediHelp rates the interaction as moderate. Brentuximab vedotin and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The cytotoxic component of brentuximab vedotin, MMAE, is metabolized by CYP3A4, so CYP3A4 inhibitors can raise its exposure and the risk of neutropenia. Isoniazid is only a weak inhibitor, so any effect is likely modest. Isoniazid also adds neuropathy and hepatotoxicity risk.
How serious is the interaction between Brentuximab vedotin and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts for neutropenia and for peripheral neuropathy. Give pyridoxine as per isoniazid practice.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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