Interações medicamentosas
Brentuximab vedotin + Itraconazole
Gravidade: Moderada
Brentuximab vedotin and Itraconazole: moderate interaction.
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Resumo
Itraconazole can increase exposure to monomethyl auristatin E (MMAE), the cytotoxic component released from brentuximab vedotin. This may raise the risk of neutropenia and peripheral neuropathy.
O que esta interação significa em palavras simples
Brentuximab vedotin and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab vedotin belongs to Oncology; Itraconazole belongs to Anti Fungals.
Por que acontece
Strong CYP3A4 inhibition (with possible P-gp inhibition) decreases MMAE clearance.
O que fazer
Monitor closely for neutropenia, neuropathy and infection during co-therapy. Consider delaying or reducing brentuximab vedotin if toxicity appears.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Itraconazole
- Alfuzosin + Itraconazole Contraindicada
- Alprazolam + Itraconazole Contraindicada
- Avanafil + Itraconazole Contraindicada
- Conivaptan + Itraconazole Contraindicada
- Dihydroergotamine intranasal + Itraconazole Contraindicada
- Dihydroergotamine + Itraconazole Contraindicada
Outras interações de Brentuximab vedotin
- Bleomycin + Brentuximab vedotin Contraindicada
- Brentuximab vedotin + Siponimod Grave
- Apalutamide + Brentuximab vedotin Moderada
- Brentuximab vedotin + Clarithromycin Moderada
- Brentuximab vedotin + Imatinib Moderada
- Brentuximab vedotin + Isoniazid Moderada
Perguntas frequentes
Can I take Brentuximab vedotin with Itraconazole?
MediHelp rates the interaction as moderate. Brentuximab vedotin and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole can increase exposure to monomethyl auristatin E (MMAE), the cytotoxic component released from brentuximab vedotin. This may raise the risk of neutropenia and peripheral neuropathy.
How serious is the interaction between Brentuximab vedotin and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for neutropenia, neuropathy and infection during co-therapy. Consider delaying or reducing brentuximab vedotin if toxicity appears.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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