Interações medicamentosas
Blinatumomab + Sirolimus
Gravidade: Moderada
Blinatumomab and Sirolimus: moderate interaction.
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Resumo
Blinatumomab causes transient cytokine release that can suppress CYP450 enzymes, mainly in the first days of each cycle. This may transiently raise sirolimus concentrations and cause toxicity.
O que esta interação significa em palavras simples
Blinatumomab and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Blinatumomab belongs to Oncology; Sirolimus belongs to Miscellaneous.
Por que acontece
Cytokine-mediated transient suppression of CYP3A4 reducing sirolimus metabolism.
O que fazer
Monitor sirolimus trough levels and toxicity during the first days of each blinatumomab cycle. Adjust the sirolimus dose as needed.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicada
- Bcg vaccine live + Sirolimus Contraindicada
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicada
- Ketoconazole + Sirolimus Contraindicada
- Levoketoconazole + Sirolimus Contraindicada
- Measles mumps and rubella vaccine live + Sirolimus Contraindicada
Outras interações de Blinatumomab
- Blinatumomab + Carbamazepine Moderada
- Blinatumomab + Cyclosporin Moderada
- Blinatumomab + Ethosuximide Moderada
- Blinatumomab + Phenytoin Moderada
- Blinatumomab + Quinidine Moderada
- Blinatumomab + Quinine Moderada
Perguntas frequentes
Can I take Blinatumomab with Sirolimus?
MediHelp rates the interaction as moderate. Blinatumomab and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Blinatumomab causes transient cytokine release that can suppress CYP450 enzymes, mainly in the first days of each cycle. This may transiently raise sirolimus concentrations and cause toxicity.
How serious is the interaction between Blinatumomab and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough levels and toxicity during the first days of each blinatumomab cycle. Adjust the sirolimus dose as needed.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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