Interações medicamentosas
Blinatumomab + Theophylline
Gravidade: Moderada
Blinatumomab and Theophylline: moderate interaction.
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Resumo
Blinatumomab causes a transient cytokine release at treatment start that can suppress CYP450 enzymes. Theophylline, a narrow therapeutic index CYP1A2 substrate, may accumulate and cause toxicity such as tachyarrhythmia, nausea or seizures.
O que esta interação significa em palavras simples
Blinatumomab and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Blinatumomab belongs to Oncology; Theophylline belongs to Respiratory.
Por que acontece
Cytokine-mediated transient suppression of hepatic CYP450 enzymes (including CYP1A2) reduces theophylline clearance.
O que fazer
Monitor theophylline serum levels and signs of toxicity during the first days of the first cycle and when restarting after an interruption. Reduce the theophylline dose if levels rise.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Theophylline
- Riociguat + Theophylline Contraindicada
- Adenosine + Theophylline Grave
- Apalutamide + Theophylline Grave
- Bupropion + Theophylline Grave
- Carvedilol + Theophylline Grave
- Cimetidine + Theophylline Grave
Outras interações de Blinatumomab
- Blinatumomab + Carbamazepine Moderada
- Blinatumomab + Cyclosporin Moderada
- Blinatumomab + Ethosuximide Moderada
- Blinatumomab + Phenytoin Moderada
- Blinatumomab + Quinidine Moderada
- Blinatumomab + Quinine Moderada
Perguntas frequentes
Can I take Blinatumomab with Theophylline?
MediHelp rates the interaction as moderate. Blinatumomab and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Blinatumomab causes a transient cytokine release at treatment start that can suppress CYP450 enzymes. Theophylline, a narrow therapeutic index CYP1A2 substrate, may accumulate and cause toxicity such as tachyarrhythmia, nausea or seizures.
How serious is the interaction between Blinatumomab and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline serum levels and signs of toxicity during the first days of the first cycle and when restarting after an interruption. Reduce the theophylline dose if levels rise.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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