Interações medicamentosas
Bupropion + Selegiline
Gravidade: Contraindicada
Bupropion and Selegiline: contraindicated interaction.
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Resumo
Selegiline (an MAO-B inhibitor that loses selectivity at higher or transdermal doses) slows catecholamine breakdown, while bupropion blocks reuptake of dopamine and noradrenaline. The combination can produce hypertensive crisis, agitation and seizures; labelling for bupropion prohibits concurrent MAOI therapy.
O que esta interação significa em palavras simples
Bupropion and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bupropion belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Por que acontece
MAO inhibition combined with dopamine and noradrenaline reuptake inhibition causes excess catecholamine activity
O que fazer
Do not use together. Wait at least 14 days after stopping selegiline before starting the other drug; allow at least a week after stopping bupropion before starting an MAOI.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Bupropion
- Bupropion + Isocarboxazid Contraindicada
- Bupropion + Linezolid Contraindicada
- Bupropion + Phenelzine Contraindicada
- Bupropion + Rasagiline Contraindicada
- Bupropion + Selegiline transdermal Contraindicada
- Bupropion + Thioridazine Contraindicada
Outras interações de Selegiline
- Amitriptyline + Selegiline Contraindicada
- Amoxapine + Selegiline Contraindicada
- Atomoxetine + Selegiline Contraindicada
- Benzphetamine + Selegiline Contraindicada
- Brimonidine + Selegiline Contraindicada
- Buprenorphine long-acting + Selegiline Contraindicada
Perguntas frequentes
Can I take Bupropion with Selegiline?
MediHelp rates the interaction as contraindicated. Bupropion and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline (an MAO-B inhibitor that loses selectivity at higher or transdermal doses) slows catecholamine breakdown, while bupropion blocks reuptake of dopamine and noradrenaline. The combination can produce hypertensive crisis, agitation and seizures; labelling for bupropion prohibits concurrent MAOI therapy.
How serious is the interaction between Bupropion and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Wait at least 14 days after stopping selegiline before starting the other drug; allow at least a week after stopping bupropion before starting an MAOI.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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