Interações medicamentosas
Bupropion + Selegiline transdermal
Gravidade: Contraindicada
Bupropion and Selegiline transdermal: contraindicated interaction.
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Resumo
Combining bupropion with a monoamine oxidase inhibitor can cause hypertensive reactions due to increased catecholamine levels. The label contraindicates this combination.
O que esta interação significa em palavras simples
Bupropion and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Bupropion inhibits dopamine and norepinephrine reuptake while MAO inhibition reduces their breakdown, producing additive catecholaminergic effects.
O que fazer
Do not coadminister. Allow at least 14 days between stopping the MAOI and starting bupropion, and likewise when switching in the other direction.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Bupropion
- Bupropion + Isocarboxazid Contraindicada
- Bupropion + Linezolid Contraindicada
- Bupropion + Phenelzine Contraindicada
- Bupropion + Rasagiline Contraindicada
- Bupropion + Selegiline Contraindicada
- Bupropion + Thioridazine Contraindicada
Perguntas frequentes
Can I take Bupropion with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Bupropion and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining bupropion with a monoamine oxidase inhibitor can cause hypertensive reactions due to increased catecholamine levels. The label contraindicates this combination.
How serious is the interaction between Bupropion and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Allow at least 14 days between stopping the MAOI and starting bupropion, and likewise when switching in the other direction.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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