Interações medicamentosas
Calcium carbonate + Delafloxacin
Gravidade: Moderada
Calcium carbonate and Delafloxacin: moderate interaction.
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Resumo
Oral delafloxacin binds to calcium and other polyvalent cations in the gut, forming poorly absorbed chelates. Systemic exposure falls and may lead to subtherapeutic antibacterial levels and treatment failure.
O que esta interação significa em palavras simples
Calcium carbonate and Delafloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Delafloxacin belongs to Anti Bacterial.
Por que acontece
Chelation of delafloxacin by calcium cations in the gastrointestinal tract reduces its oral absorption.
O que fazer
Give oral delafloxacin at least 2 hours before or 6 hours after calcium carbonate. Alternatively use intravenous delafloxacin if separation is not feasible.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Calcium carbonate
Outras interações de Delafloxacin
- Aluminum hydroxide + Delafloxacin Moderada
- Calcium + Delafloxacin Moderada
- Carbonyl iron + Delafloxacin Moderada
- Delafloxacin + Didanosine Moderada
- Delafloxacin + Ferrous fumarate Moderada
- Delafloxacin + Ferrous gluconate Moderada
Perguntas frequentes
Can I take Calcium carbonate with Delafloxacin?
MediHelp rates the interaction as moderate. Calcium carbonate and Delafloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral delafloxacin binds to calcium and other polyvalent cations in the gut, forming poorly absorbed chelates. Systemic exposure falls and may lead to subtherapeutic antibacterial levels and treatment failure.
How serious is the interaction between Calcium carbonate and Delafloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral delafloxacin at least 2 hours before or 6 hours after calcium carbonate. Alternatively use intravenous delafloxacin if separation is not feasible.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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