Interações medicamentosas
Cannabidiol + Dronabinol
Gravidade: Moderada
Cannabidiol and Dronabinol: moderate interaction.
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Resumo
Cannabidiol inhibits CYP2C9 and CYP3A4 and may raise dronabinol (THC) concentrations, increasing psychoactive effects such as sedation, dizziness and tachycardia. Both agents also have additive CNS effects.
O que esta interação significa em palavras simples
Cannabidiol and Dronabinol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Dronabinol belongs to Central Nervous System.
Por que acontece
Cannabidiol inhibits CYP2C9 and CYP3A4 metabolism of dronabinol, plus additive CNS effects.
O que fazer
Monitor for excessive sedation, cognitive impairment and tachycardia; reduce the dronabinol dose if adverse effects appear.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Dronabinol
- Cefotetan + Dronabinol Contraindicada
- Disulfiram + Dronabinol Contraindicada
- Dronabinol + Midazolam intranasal Grave
- Dronabinol + Zuranolone Grave
- Amobarbital + Dronabinol Moderada
- Apalutamide + Dronabinol Moderada
Outras interações de Cannabidiol
- Cannabidiol + Phenytoin Grave
- Cannabidiol + Sodium valproate Grave
- Cannabidiol + Tacrolimus Grave
- Abiraterone + Cannabidiol Moderada
- Alogliptin-pioglitazone + Cannabidiol Moderada
- Amiodarone + Cannabidiol Moderada
Perguntas frequentes
Can I take Cannabidiol with Dronabinol?
MediHelp rates the interaction as moderate. Cannabidiol and Dronabinol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol inhibits CYP2C9 and CYP3A4 and may raise dronabinol (THC) concentrations, increasing psychoactive effects such as sedation, dizziness and tachycardia. Both agents also have additive CNS effects.
How serious is the interaction between Cannabidiol and Dronabinol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, cognitive impairment and tachycardia; reduce the dronabinol dose if adverse effects appear.
What other medicines interact with Dronabinol?
MediHelp also lists interactions of Dronabinol with, for example, Cefotetan, Disulfiram, Midazolam intranasal. The full list is on the Dronabinol page.
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