Interações medicamentosas
Caspofungin + Cyclosporine
Gravidade: Moderada
Caspofungin and Cyclosporine: moderate interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Cyclosporine increases caspofungin exposure, and transient rises in liver transaminases have been seen when the two are given together. Caspofungin does not meaningfully change cyclosporine levels.
O que esta interação significa em palavras simples
Caspofungin and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Cyclosporine inhibits OATP-mediated hepatic uptake of caspofungin, raising its plasma concentrations.
O que fazer
Monitor liver enzymes during coadministration and consider stopping if significant hepatic abnormalities develop.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Caspofungin
- Apalutamide + Caspofungin Moderada
- Carbamazepine + Caspofungin Moderada
- Caspofungin + Cyclosporin Moderada
- Caspofungin + Dexamethasone Moderada
- Caspofungin + Efavirenz Moderada
- Caspofungin + Fosphenytoin Moderada
Perguntas frequentes
Can I take Caspofungin with Cyclosporine?
MediHelp rates the interaction as moderate. Caspofungin and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine increases caspofungin exposure, and transient rises in liver transaminases have been seen when the two are given together. Caspofungin does not meaningfully change cyclosporine levels.
How serious is the interaction between Caspofungin and Cyclosporine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes during coadministration and consider stopping if significant hepatic abnormalities develop.
What other medicines interact with Caspofungin?
MediHelp also lists interactions of Caspofungin with, for example, Apalutamide, Carbamazepine, Cyclosporin. The full list is on the Caspofungin page.
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