Interações medicamentosas
Caspofungin + Fosphenytoin
Gravidade: Moderada
Caspofungin and Fosphenytoin: moderate interaction.
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Resumo
Fosphenytoin is converted to phenytoin, an inducer that can lower caspofungin concentrations. The clinical impact is uncertain but could reduce antifungal efficacy in serious infection.
O que esta interação significa em palavras simples
Caspofungin and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Caspofungin belongs to Anti Fungals; Fosphenytoin belongs to Central Nervous System.
Por que acontece
Phenytoin induces clearance pathways of caspofungin, lowering exposure.
O que fazer
Caspofungin labeling suggests considering a daily dose of 70 mg when given with inducers such as phenytoin in patients not responding adequately. Monitor clinical response.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Caspofungin
- Apalutamide + Caspofungin Moderada
- Carbamazepine + Caspofungin Moderada
- Caspofungin + Cyclosporin Moderada
- Caspofungin + Cyclosporine Moderada
- Caspofungin + Dexamethasone Moderada
- Caspofungin + Efavirenz Moderada
Outras interações de Fosphenytoin
- Dronedarone + Fosphenytoin Contraindicada
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicada
- Fosphenytoin + Lorlatinib Contraindicada
- Fosphenytoin + Lurasidone Contraindicada
- Fosphenytoin + Ranolazine Contraindicada
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicada
Perguntas frequentes
Can I take Caspofungin with Fosphenytoin?
MediHelp rates the interaction as moderate. Caspofungin and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosphenytoin is converted to phenytoin, an inducer that can lower caspofungin concentrations. The clinical impact is uncertain but could reduce antifungal efficacy in serious infection.
How serious is the interaction between Caspofungin and Fosphenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Caspofungin labeling suggests considering a daily dose of 70 mg when given with inducers such as phenytoin in patients not responding adequately. Monitor clinical response.
What other medicines interact with Caspofungin?
MediHelp also lists interactions of Caspofungin with, for example, Apalutamide, Carbamazepine, Cyclosporin. The full list is on the Caspofungin page.
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