Interações medicamentosas
Caspofungin + Efavirenz
Gravidade: Moderada
Caspofungin and Efavirenz: moderate interaction.
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Resumo
Efavirenz may lower caspofungin exposure, which could reduce antifungal efficacy. Caspofungin labeling lists efavirenz among inducers for which a higher dose may be considered.
O que esta interação significa em palavras simples
Caspofungin and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Caspofungin belongs to Anti Fungals; Efavirenz belongs to Anti Virals.
Por que acontece
Proposed induction of caspofungin clearance by efavirenz; the exact mechanism is not firmly established.
O que fazer
Consider increasing caspofungin to 70 mg daily in adults if the response is inadequate, and monitor clinical response.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Caspofungin
- Apalutamide + Caspofungin Moderada
- Carbamazepine + Caspofungin Moderada
- Caspofungin + Cyclosporin Moderada
- Caspofungin + Cyclosporine Moderada
- Caspofungin + Dexamethasone Moderada
- Caspofungin + Fosphenytoin Moderada
Outras interações de Efavirenz
- Cobimetinib + Efavirenz Contraindicada
- Dienogest / estradiol valerate + Efavirenz Contraindicada
- Dihydroergotamine intranasal + Efavirenz Contraindicada
- Dihydroergotamine + Efavirenz Contraindicada
- Doravirine + Efavirenz Contraindicada
- Efavirenz + Elbasvir / grazoprevir Contraindicada
Perguntas frequentes
Can I take Caspofungin with Efavirenz?
MediHelp rates the interaction as moderate. Caspofungin and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz may lower caspofungin exposure, which could reduce antifungal efficacy. Caspofungin labeling lists efavirenz among inducers for which a higher dose may be considered.
How serious is the interaction between Caspofungin and Efavirenz?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider increasing caspofungin to 70 mg daily in adults if the response is inadequate, and monitor clinical response.
What other medicines interact with Caspofungin?
MediHelp also lists interactions of Caspofungin with, for example, Apalutamide, Carbamazepine, Cyclosporin. The full list is on the Caspofungin page.
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