Interações medicamentosas
Caspofungin + Cyclosporin
Gravidade: Moderada
Caspofungin and Cyclosporin: moderate interaction.
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Resumo
Cyclosporine raises caspofungin exposure, and transient elevations of liver transaminases have been seen with the combination. Caspofungin does not materially change cyclosporine levels.
O que esta interação significa em palavras simples
Caspofungin and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Caspofungin belongs to Anti Fungals; Cyclosporin belongs to Miscellaneous.
Por que acontece
Cyclosporine inhibits OATP1B1-mediated hepatic uptake of caspofungin, raising its plasma concentrations.
O que fazer
Monitor liver enzymes during concurrent therapy and discontinue if clinically significant hepatotoxicity develops.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicada
- Aliskiren + Cyclosporin Contraindicada
- Bcg vaccine live + Cyclosporin Contraindicada
- Bosentan + Cyclosporin Contraindicada
- Cidofovir + Cyclosporin Contraindicada
- Cyclosporin + Dengue vaccine Contraindicada
Outras interações de Caspofungin
- Apalutamide + Caspofungin Moderada
- Carbamazepine + Caspofungin Moderada
- Caspofungin + Cyclosporine Moderada
- Caspofungin + Dexamethasone Moderada
- Caspofungin + Efavirenz Moderada
- Caspofungin + Fosphenytoin Moderada
Perguntas frequentes
Can I take Caspofungin with Cyclosporin?
MediHelp rates the interaction as moderate. Caspofungin and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine raises caspofungin exposure, and transient elevations of liver transaminases have been seen with the combination. Caspofungin does not materially change cyclosporine levels.
How serious is the interaction between Caspofungin and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes during concurrent therapy and discontinue if clinically significant hepatotoxicity develops.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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