Interações medicamentosas
Cefazolin + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Gravidade: Moderada
Cefazolin and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Sodium picosulfate is a prodrug that must be converted to its active laxative form by colonic bacteria. Antibiotics that suppress colonic flora may reduce this activation and lead to poorer bowel cleansing before colonoscopy. Cefazolin is given parenterally, so the effect is likely smaller than with oral antibiotics, but labeling advises caution.
O que esta interação significa em palavras simples
Cefazolin and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Antibiotic suppression of colonic bacteria needed to convert sodium picosulfate to its active metabolite.
O que fazer
Assess bowel preparation adequacy before the procedure and consider extra preparation or rescheduling if cleansing is poor. Where possible, avoid starting antibiotics around the time of the preparation.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cefazolin
- Amikacin + Cefazolin Moderada
- Bcg vaccine live + Cefazolin Moderada
- Cefazolin + Cholera vaccine Moderada
- Cefazolin + Dexamethasone-tobramycin Moderada
- Cefazolin + Gentamicin Moderada
- Cefazolin + Kanamycin Moderada
Perguntas frequentes
Can I take Cefazolin with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Cefazolin and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium picosulfate is a prodrug that must be converted to its active laxative form by colonic bacteria. Antibiotics that suppress colonic flora may reduce this activation and lead to poorer bowel cleansing before colonoscopy. Cefazolin is given parenterally, so the effect is likely smaller than with oral antibiotics, but labeling advises caution.
How serious is the interaction between Cefazolin and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess bowel preparation adequacy before the procedure and consider extra preparation or rescheduling if cleansing is poor. Where possible, avoid starting antibiotics around the time of the preparation.
What other medicines interact with Cefazolin?
MediHelp also lists interactions of Cefazolin with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefazolin page.
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