Interações medicamentosas
Cefepime + Tobramycin
Gravidade: Moderada
Cefepime and Tobramycin: moderate interaction.
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Resumo
Tobramycin can injure the kidneys and inner ear, and use alongside a cephalosporin has been linked in some reports to further renal impairment. Cefepime has limited intrinsic nephrotoxicity, so the added risk is generally modest but greater in renal impairment, older patients and prolonged courses.
O que esta interação significa em palavras simples
Cefepime and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefepime belongs to Anti Bacterial; Tobramycin belongs to Anti Bacterial.
Por que acontece
Additive renal tubular stress; reduced renal function increases aminoglycoside accumulation and thus toxicity.
O que fazer
Monitor serum creatinine and tobramycin trough levels, and adjust doses to renal function. Keep the combination as short as possible and ask about hearing or balance changes.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cefepime
- Amikacin + Cefepime Moderada
- Cefepime + Cholera vaccine Moderada
- Cefepime + Dexamethasone-tobramycin Moderada
- Cefepime + Gentamicin Moderada
- Cefepime + Kanamycin Moderada
- Cefepime + Microbiota Moderada
Outras interações de Tobramycin
- Cidofovir + Tobramycin Contraindicada
- Adefovir + Tobramycin Grave
- Amikacin + Tobramycin Grave
- Amphotericin b deoxycholate + Tobramycin Grave
- Amphotericin b + Tobramycin Grave
- Atracurium + Tobramycin Grave
Perguntas frequentes
Can I take Cefepime with Tobramycin?
MediHelp rates the interaction as moderate. Cefepime and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tobramycin can injure the kidneys and inner ear, and use alongside a cephalosporin has been linked in some reports to further renal impairment. Cefepime has limited intrinsic nephrotoxicity, so the added risk is generally modest but greater in renal impairment, older patients and prolonged courses.
How serious is the interaction between Cefepime and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and tobramycin trough levels, and adjust doses to renal function. Keep the combination as short as possible and ask about hearing or balance changes.
What other medicines interact with Cefepime?
MediHelp also lists interactions of Cefepime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefepime page.
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