Drug interactions
Cefpirome + Gentamicin
Severity: Moderate
Cefpirome and Gentamicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalosporins have been reported to add to aminoglycoside nephrotoxicity, though the effect is generally modest with newer agents. Concurrent use may modestly raise the risk of renal impairment, particularly in patients with existing kidney disease or dehydration.
What this interaction means in plain words
Cefpirome and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefpirome belongs to Anti Bacterial; Gentamicin belongs to Anti Bacterial.
Why it happens
Possible additive renal tubular injury; the mechanism is not firmly established.
What to do
Monitor serum creatinine during combined therapy and adjust doses to renal function. Check gentamicin levels in patients at risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Other interactions of Cefpirome
- Amikacin + Cefpirome Moderate
- Bupropion-naltrexone + Cefpirome Moderate
- Bupropion + Cefpirome Moderate
- Cefpirome + Dexamethasone-tobramycin Moderate
- Cefpirome + Streptomycin Moderate
- Acetylsalicylic acid + Cefpirome Minor
Frequently asked questions
Can I take Cefpirome with Gentamicin?
MediHelp rates the interaction as moderate. Cefpirome and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cephalosporins have been reported to add to aminoglycoside nephrotoxicity, though the effect is generally modest with newer agents. Concurrent use may modestly raise the risk of renal impairment, particularly in patients with existing kidney disease or dehydration.
How serious is the interaction between Cefpirome and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine during combined therapy and adjust doses to renal function. Check gentamicin levels in patients at risk.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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