Interações medicamentosas
Chenodeoxycholic acid + Phenobarbitone
Gravidade: Moderada
Chenodeoxycholic acid and Phenobarbitone: moderate interaction.
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Resumo
Phenobarbital can induce HMG-CoA reductase and bile acid synthesis, which may counteract the intended suppression of abnormal bile acid production by chenodeoxycholic acid. Therapeutic effect may be reduced.
O que esta interação significa em palavras simples
Chenodeoxycholic acid and Phenobarbitone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chenodeoxycholic acid belongs to Gastrointestinal Tract; Phenobarbitone belongs to Central Nervous System.
Por que acontece
Enzyme induction by phenobarbital increases cholesterol and bile acid synthesis, opposing chenodeoxycholic acid feedback inhibition.
O que fazer
Monitor urinary or serum bile alcohols and adjust the chenodeoxycholic acid dose as needed. Consider a non-inducing anticonvulsant if appropriate.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Chenodeoxycholic acid
Outras interações de Phenobarbitone
- Cabotegravir + Phenobarbitone Contraindicada
- Doravirine + Phenobarbitone Contraindicada
- Isavuconazole + Phenobarbitone Contraindicada
- Darolutamide + Phenobarbitone Grave
- Finerenone + Phenobarbitone Grave
- Ivacaftor + Phenobarbitone Grave
Perguntas frequentes
Can I take Chenodeoxycholic acid with Phenobarbitone?
MediHelp rates the interaction as moderate. Chenodeoxycholic acid and Phenobarbitone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital can induce HMG-CoA reductase and bile acid synthesis, which may counteract the intended suppression of abnormal bile acid production by chenodeoxycholic acid. Therapeutic effect may be reduced.
How serious is the interaction between Chenodeoxycholic acid and Phenobarbitone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary or serum bile alcohols and adjust the chenodeoxycholic acid dose as needed. Consider a non-inducing anticonvulsant if appropriate.
What other medicines interact with Chenodeoxycholic acid?
MediHelp also lists interactions of Chenodeoxycholic acid with, for example, Cyclosporin, Sirolimus, Aluminum hydroxide. The full list is on the Chenodeoxycholic acid page.
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