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Interações medicamentosas

Chenodeoxycholic acid + Colestipol

Gravidade: Moderada

Chenodeoxycholic acid and Colestipol: moderate interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

Colestipol is a bile acid sequestrant that binds bile acids in the intestine. It reduces absorption of chenodeoxycholic acid and may lessen its efficacy.

O que esta interação significa em palavras simples

Chenodeoxycholic acid and Colestipol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Chenodeoxycholic acid belongs to Gastrointestinal Tract; Colestipol belongs to Cardiovascular.

Nível de evidência: High

Por que acontece

Colestipol binds chenodeoxycholic acid in the gut, preventing absorption and enterohepatic recirculation.

O que fazer

Give chenodeoxycholic acid at least 2 hours before or after colestipol. Monitor response, or choose an alternative lipid-lowering agent.

O que perguntar ao farmacêutico

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Chenodeoxycholic acid with Colestipol?

MediHelp rates the interaction as moderate. Chenodeoxycholic acid and Colestipol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colestipol is a bile acid sequestrant that binds bile acids in the intestine. It reduces absorption of chenodeoxycholic acid and may lessen its efficacy.

How serious is the interaction between Chenodeoxycholic acid and Colestipol?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give chenodeoxycholic acid at least 2 hours before or after colestipol. Monitor response, or choose an alternative lipid-lowering agent.

What other medicines interact with Chenodeoxycholic acid?

MediHelp also lists interactions of Chenodeoxycholic acid with, for example, Cyclosporin, Sirolimus, Aluminum hydroxide. The full list is on the Chenodeoxycholic acid page.

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