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Interações medicamentosas

Dihydroergotamine + Eletriptan

Gravidade: Contraindicada

Dihydroergotamine and Eletriptan: contraindicated interaction.

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Resumo

Eletriptan and dihydroergotamine both constrict blood vessels, and together they may produce prolonged vasospasm. Cardiac and cerebral ischemia are the concern.

O que esta interação significa em palavras simples

Dihydroergotamine and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Dihydroergotamine belongs to Central Nervous System; Eletriptan belongs to Central Nervous System.

Nível de evidência: High

Por que acontece

Additive vasoconstriction via 5-HT1B/1D agonism and ergot vascular receptor effects; dihydroergotamine is also a CYP3A4 substrate.

O que fazer

Avoid together and separate by at least 24 hours. Use only one agent per attack.

O que perguntar ao farmacêutico

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

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Perguntas frequentes

Can I take Dihydroergotamine with Eletriptan?

MediHelp rates the interaction as contraindicated. Dihydroergotamine and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Eletriptan and dihydroergotamine both constrict blood vessels, and together they may produce prolonged vasospasm. Cardiac and cerebral ischemia are the concern.

How serious is the interaction between Dihydroergotamine and Eletriptan?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid together and separate by at least 24 hours. Use only one agent per attack.

What other medicines interact with Eletriptan?

MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.

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