Interações medicamentosas
Clarithromycin + Ranolazine
Gravidade: Contraindicada
Clarithromycin and Ranolazine: contraindicated interaction.
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Resumo
Clarithromycin markedly raises ranolazine concentrations, increasing dose-related QT prolongation, dizziness and nausea. Ranolazine is contraindicated with strong CYP3A inhibitors.
O que esta interação significa em palavras simples
Clarithromycin and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Ranolazine belongs to Cardiovascular.
Por que acontece
Strong CYP3A4 and P-gp inhibition reduces ranolazine metabolism and clearance.
O que fazer
Do not combine; use azithromycin or another antibiotic, or withhold ranolazine during a short clarithromycin course.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Clarithromycin
- Astemizole + Clarithromycin Contraindicada
- Avanafil + Clarithromycin Contraindicada
- Cisapride + Clarithromycin Contraindicada
- Clarithromycin + Colchicine Contraindicada
- Clarithromycin + Conivaptan Contraindicada
- Clarithromycin + Dihydroergotamine Contraindicada
Outras interações de Ranolazine
- Adagrasib + Ranolazine Contraindicada
- Amobarbital + Ranolazine Contraindicada
- Apalutamide + Ranolazine Contraindicada
- Butabarbital + Ranolazine Contraindicada
- Carbamazepine + Ranolazine Contraindicada
- Cobicistat + Ranolazine Contraindicada
Perguntas frequentes
Can I take Clarithromycin with Ranolazine?
MediHelp rates the interaction as contraindicated. Clarithromycin and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin markedly raises ranolazine concentrations, increasing dose-related QT prolongation, dizziness and nausea. Ranolazine is contraindicated with strong CYP3A inhibitors.
How serious is the interaction between Clarithromycin and Ranolazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use azithromycin or another antibiotic, or withhold ranolazine during a short clarithromycin course.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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