Interações medicamentosas
Clomipramine + Givinostat
Gravidade: Grave
Clomipramine and Givinostat: major interaction.
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Resumo
Both drugs can prolong the QT interval, so combining them raises the risk of torsades de pointes. Givinostat labeling recommends avoiding combination with QT-prolonging drugs.
O que esta interação significa em palavras simples
Clomipramine and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Givinostat belongs to Miscellaneous.
Por que acontece
Additive QT prolongation.
O que fazer
Avoid if possible; otherwise obtain ECGs at initiation and during use and withhold treatment if QTc becomes markedly prolonged. Correct potassium and magnesium abnormalities.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Clomipramine
- Arsenic trioxide + Clomipramine Contraindicada
- Clomipramine + Dofetilide Contraindicada
- Clomipramine + Droperidol Contraindicada
- Clomipramine + Isocarboxazid Contraindicada
- Clomipramine + Methylene blue Contraindicada
- Clomipramine + Pentamidine Contraindicada
Outras interações de Givinostat
- Abiraterone + Givinostat Grave
- Amiodarone + Givinostat Grave
- Amisulpride + Givinostat Grave
- Amitriptyline + Givinostat Grave
- Anagrelide + Givinostat Grave
- Asenapine + Givinostat Grave
Perguntas frequentes
Can I take Clomipramine with Givinostat?
MediHelp rates the interaction as major. Clomipramine and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combining them raises the risk of torsades de pointes. Givinostat labeling recommends avoiding combination with QT-prolonging drugs.
How serious is the interaction between Clomipramine and Givinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise obtain ECGs at initiation and during use and withhold treatment if QTc becomes markedly prolonged. Correct potassium and magnesium abnormalities.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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