Interações medicamentosas
Clomipramine + Umeclidinium-vilanterol
Gravidade: Grave
Clomipramine and Umeclidinium-vilanterol: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Tricyclic antidepressants can potentiate the cardiovascular effects of beta-agonists such as vilanterol, causing tachycardia, hypertension and arrhythmia. Clomipramine also prolongs QT and has anticholinergic effects that may add to umeclidinium.
O que esta interação significa em palavras simples
Clomipramine and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Umeclidinium-vilanterol belongs to Respiratory.
Por que acontece
Additive adrenergic cardiovascular stimulation and QT prolongation, with additive anticholinergic effects.
O que fazer
Avoid the combination where possible, or use with close monitoring of heart rate, blood pressure and ECG. Watch for anticholinergic effects such as urinary retention and dry mouth.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Clomipramine e Umeclidinium-vilanterol, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Umeclidinium-vilanterol
Outras interações de Clomipramine
- Arsenic trioxide + Clomipramine Contraindicada
- Clomipramine + Dofetilide Contraindicada
- Clomipramine + Droperidol Contraindicada
- Clomipramine + Isocarboxazid Contraindicada
- Clomipramine + Methylene blue Contraindicada
- Clomipramine + Pentamidine Contraindicada
Perguntas frequentes
Can I take Clomipramine with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Clomipramine and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclic antidepressants can potentiate the cardiovascular effects of beta-agonists such as vilanterol, causing tachycardia, hypertension and arrhythmia. Clomipramine also prolongs QT and has anticholinergic effects that may add to umeclidinium.
How serious is the interaction between Clomipramine and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use with close monitoring of heart rate, blood pressure and ECG. Watch for anticholinergic effects such as urinary retention and dry mouth.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
